Biosynthetic proline/alanine random coil polypeptides and their uses

Biosynthetic proline/alanine random coil polypeptides and their uses

  • CN 102,883,734 A
  • Filed: 05/20/2011
  • Published: 01/16/2013
  • Est. Priority Date: 05/21/2010
  • Status: Active Application
First Claim
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1. drug conjugate comprises(i) biosynthetic random coil polypeptide or polypeptide section, described polypeptide or polypeptide section comprise the aminoacid sequence that only is comprised of proline and the amino sour residue of alanine, wherein said aminoacid sequence is comprised of at least 50 proline (Pro) and alanine (Ala) amino acid residue, and(ii) medicine, described medicine are selected from (a) and comprise and have or mediate bioactive aminoacid sequence or have or mediate biological activity protein or the polypeptide of bioactive aminoacid sequence, and (b) small-molecule drug.

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