The proline of biosynthesis/alanine random coil polypeptide and application thereof

The proline of biosynthesis/alanine random coil polypeptide and application thereof

  • CN 102,883,734 B
  • Filed: 05/20/2011
  • Issued: 01/02/2018
  • Est. Priority Date: 05/21/2010
  • Status: Active Grant
First Claim
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1. drug conjugate, comprising(i) the random coil polypeptide or polypeptide section of biosynthesis, polypeptide or the polypeptide section is by only by proline and the third ammoniaThe amino acid sequence composition of sour amino acid residue composition, wherein the amino acid sequence is by least 50 proline (Pro) and thirdPropylhomoserin (Ala) amino acid residue forms, wherein the composition part of the random coil polypeptide or polypeptide section is by selected from followingAmino acid sequence forms:

  • AAPAAPAPAAPAAPAPAAPA(SEQ ID NO;

    1), andAAAPAAAPAAAPAAAPAAAP(SEQ ID NO;

    3), and(ii) medicine, the medicine be selected from (a) include with or mediation bioactivity amino acid sequence or with or mediateThe biological activity protein or polypeptide of the amino acid sequence of bioactivity, and (b) small-molecule drug.

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