Anti-polyubiquitin antibodies and methods of using the same and application method

Anti-polyubiquitin antibodies and methods of using the same and application method

  • CN 102,947,335 B
  • Filed: 04/14/2011
  • Issued: 11/06/2018
  • Est. Priority Date: 04/15/2010
  • Status: Active Grant
First Claim
Patent Images

1. a kind of antibody of the separation of the poly ubiquitin of combination K11 connections, the wherein antibody include:

  • a)SEQ ID NO;

    2 HVR-L1 sequences, SEQ ID NO;

    3 HVR-L2 sequences, SEQ ID NO;

    4 HVR-L3 sequencesRow, SEQ ID NO;

    11 HVR-H1 sequences, SEQ ID NO;

    17 HVR-H2 sequences and SEQ ID NO;

    23 HVR-H3 sequencesRow;

    b)SEQ ID NO;

    2 HVR-L1 sequences, SEQ ID NO;

    3 HVR-L2 sequences, SEQ ID NO;

    4 HVR-L3 sequencesRow, SEQ ID NO;

    6 HVR-H1 sequences, SEQ ID NO;

    12 HVR-H2 sequences and SEQ ID NO;

    18 HVR-H3 sequencesRow;

    c)SEQ ID NO;

    2 HVR-L1 sequences, SEQ ID NO;

    3 HVR-L2 sequences, SEQ ID NO;

    4 HVR-L3 sequencesRow, SEQ ID NO;

    7 HVR-H1 sequences, SEQ ID NO;

    13 HVR-H2 sequences and SEQ ID NO;

    19 HVR-H3 sequencesRow;

    d)SEQ ID NO;

    2 HVR-L1 sequences, SEQ ID NO;

    3 HVR-L2 sequences, SEQ ID NO;

    4 HVR-L3 sequencesRow, SEQ ID NO;

    8 HVR-H1 sequences, SEQ ID NO;

    14 HVR-H2 sequences and SEQ ID NO;

    20 HVR-H3 sequencesRow;

    e)SEQ ID NO;

    2 HVR-L1 sequences, SEQ ID NO;

    3 HVR-L2 sequences, SEQ ID NO;

    4 HVR-L3 sequencesRow, SEQ ID NO;

    9 HVR-H1 sequences, SEQ ID NO;

    15 HVR-H2 sequences and SEQ ID NO;

    21 HVR-H3 sequencesRow;

    f)SEQ ID NO;

    2 HVR-L1 sequences, SEQ ID NO;

    3 HVR-L2 sequences, SEQ ID NO;

    4 HVR-L3 sequencesRow, SEQ ID NO;

    10 HVR-H1 sequences, SEQ ID NO;

    16 HVR-H2 sequences and SEQ ID NO;

    22 HVR-H3 sequencesRow;

    g)SEQ ID NO;

    2 HVR-L1 sequences, SEQ ID NO;

    61 HVR-L2 sequences, SEQ ID NO;

    4 HVR-L3 sequencesRow, SEQ ID NO;

    11 HVR-H1 sequences, SEQ ID NO;

    17 HVR-H2 sequences and SEQ ID NO;

    23 HVR-H3 sequencesRow;

    h)SEQ ID NO;

    57 HVR-L1 sequences, SEQ ID NO;

    3 HVR-L2 sequences, SEQ ID NO;

    4 HVR-L3 sequencesRow, SEQ ID NO;

    11 HVR-H1 sequences, SEQ ID NO;

    17 HVR-H2 sequences and SEQ ID NO;

    23 HVR-H3 sequencesRow;

    i)SEQ ID NO;

    58 HVR-L1 sequences, SEQ ID NO;

    3 HVR-L2 sequences, SEQ ID NO;

    4 HVR-L3 sequencesRow, SEQ ID NO;

    11 HVR-H1 sequences, SEQ ID NO;

    17 HVR-H2 sequences and SEQ ID NO;

    23 HVR-H3 sequencesRow;

    j)SEQ ID NO;

    59 HVR-L1 sequences, SEQ ID NO;

    3 HVR-L2 sequences, SEQ ID NO;

    4 HVR-L3 sequencesRow, SEQ ID NO;

    11 HVR-H1 sequences, SEQ ID NO;

    17 HVR-H2 sequences and SEQ ID NO;

    23 HVR-H3 sequencesRow;

    k)SEQ ID NO;

    60 HVR-L1 sequences, SEQ ID NO;

    3 HVR-L2 sequences, SEQ ID NO;

    4 HVR-L3 sequencesRow, SEQ ID NO;

    11 HVR-H1 sequences, SEQ ID NO;

    17 HVR-H2 sequences and SEQ ID NO;

    23 HVR-H3 sequencesRow;

    l)SEQ ID NO;

    2 HVR-L1 sequences, SEQ ID NO;

    3 HVR-L2 sequences, SEQ ID NO;

    4 HVR-L3 sequencesRow, SEQ ID NO;

    11 HVR-H1 sequences, SEQ ID NO;

    17 HVR-H2 sequences and SEQ ID NO;

    68 HVR-H3 sequencesRow;

    m)SEQ ID NO;

    2 HVR-L1 sequences, SEQ ID NO;

    3 HVR-L2 sequences, SEQ ID NO;

    4 HVR-L3 sequencesRow, SEQ ID NO;

    11 HVR-H1 sequences, SEQ ID NO;

    17 HVR-H2 sequences and SEQ ID NO;

    69 HVR-H3 sequencesRow;

    n)SEQ ID NO;

    2 HVR-L1 sequences, SEQ ID NO;

    3 HVR-L2 sequences, SEQ ID NO;

    4 HVR-L3 sequencesRow, SEQ ID NO;

    11 HVR-H1 sequences, SEQ ID NO;

    67 HVR-H2 sequences and SEQ ID NO;

    23 HVR-H3 sequencesRow;

    o)SEQ ID NO;

    58 HVR-L1 sequences, SEQ ID NO;

    3 HVR-L2 sequences, SEQ ID NO;

    4 HVR-L3 sequencesRow, SEQ ID NO;

    11 HVR-H1 sequences, SEQ ID NO;

    67 HVR-H2 sequences and SEQ ID NO;

    23 HVR-H3 sequencesRow;

    Orp)SEQ ID NO;

    59 HVR-L1 sequences, SEQ ID NO;

    3 HVR-L2 sequences, SEQ ID NO;

    4 HVR-L3 sequencesRow, SEQ ID NO;

    11 HVR-H1 sequences, SEQ ID NO;

    67 HVR-H2 sequences and SEQ ID NO;

    23 HVR-H3 sequencesRow.

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