Method for reprogramming T cells and hematophietic cells

Method for reprogramming T cells and hematophietic cells

  • CN 103,087,991 A
  • Filed: 06/04/2010
  • Published: 05/08/2013
  • Est. Priority Date: 06/05/2009
  • Status: Active Application
First Claim
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1. be used for producing from the CD34+ hemopoietic progenitor cell in vitro method of the multipotential stem cell of inducing, comprise the following steps:

  • (a) obtain to comprise the cell colony of CD34+ hemopoietic progenitor cell, wherein said CD34 +Hemopoietic progenitor cell does not pass through from;

    its cell the experimenter that the granulocyte colony-stimulating factor (G-CSF) of external application is mobilized;

    With (b) use expression transcription factor Sox2, Oct4, the virus of c-Myc and Klf-4 or expression transcription factor Sox2, Oct4, the described CD34 of virus transduction of Nanog and Lin28 +Hemopoietic progenitor cell is to provide the iPS cell colony.

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