Stable effervescent bisphosphonate formulations with rapid solubilization characteristics

Stable effervescent bisphosphonate formulations with rapid solubilization characteristics

  • CN 103,140,220 A
  • Filed: 12/05/2011
  • Published: 06/05/2013
  • Est. Priority Date: 12/06/2010
  • Status: Active Application
First Claim
Patent Images

1. a stable effervescent tablet, effervescent granule or effervescent dust composition, described compositions do not contain can with the excipient of effervescent organic acid composition reaction, and comprise:

  • The Diphosphonate bone resorption inhibitor of effective dose,The effervescent organic acid composition,The effervescent base component,Wherein, described compositions does not contain polyhydric alcohol binding agent and tabletting lubricant;

    Have 0.25% (m/m) or drying loss still less;

    When putting into the water of 3~

    8 fluid ounces at the temperature between 5 ℃



    20 ℃

    , have and be no more than the complete disintegration time of 180 seconds;

    And described Diphosphonate adds with micronized particle or by spray drying, and be dissolved in water fully in 2 minutes in, and need not stir.

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