Dual-acting pharmaceutical compositions based on superstructures of angiotensin receptor antagonist/blocker (arb) and neutral endopeptidase (nep) inhibitor

Dual-acting pharmaceutical compositions based on superstructures of angiotensin receptor antagonist/blocker (arb) and neutral endopeptidase (nep) inhibitor

CN
  • CN 103,251,587 A
  • Filed: 11/04/2008
  • Published: 08/21/2013
  • Est. Priority Date: 11/06/2007
  • Status: Active Application
First Claim
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1. solid oral dosage form, it comprises:

  • (a) concentration is the dual function complex of composition weight 4% to 90%;

    With(b) at least a pharmaceutically acceptable excipient,Wherein said dual function complex is [3-((1S;

    3R)-and 1-biphenyl-4-ylmethyl-3-ethoxy carbonyl-1-butyl carbamoyl) propanoic acid-(S)-3'"'"'-methyl-2'"'"'-(valeryl 2 "-(tetrazolium-5-base anion) biphenyl-4'"'"'-ylmethyl } amino) butanoic acid] trisodium half pentahydrateWherein said dual function complex with the per unit dosage form be 40,50,100,200 or the effective dose of 400mg exist, andWherein said solid oral dosage form has following external dissolution characteristic;

    after 10 minutes, average 10% valsartan free acid or its officinal salt to average 100% (by weight) is released.

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