Guanidine compounds and compositions for the inhibition of nampt

Guanidine compounds and compositions for the inhibition of nampt

  • CN 103,261,160 A
  • Filed: 09/02/2011
  • Published: 08/21/2013
  • Est. Priority Date: 09/03/2010
  • Status: Active Application
First Claim
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1. the compound of formula II and pharmaceutical salts thereof:

  • Wherein Ar 1Be aryl or heteroaryl, wherein said aryl or heteroaryl are unsubstituted or replace Have one or more independently to be selected from following substituting group;

    Deuterium, halogen, cyano group, alkyl, cyano group alkyl, haloalkyl, thiazolinyl, alkynyl, alkoxyl group, halogenated alkoxy, aryloxy ,-NR aR b,-C (O) N (R aR b) ,-C (O)-alkyl ,-C (O)-aryl ,-S (O)-aryl ,-NH-C (O)-alkyl ,-NH-C (O)-aryl, (alkoxyalkyl) oxygen base-, cycloalkyl, Heterocyclylalkyl, aryl, and heteroaryl;

    Ar 2Be unsubstituted aryl or heteroaryl;

    R 1Be cycloalkyl, aryl, Heterocyclylalkyl or heteroaryl, (i) each in wherein said cycloalkyl, aryl, Heterocyclylalkyl and the heteroaryl is for unsubstituted or randomly independent the replacement has 1,2,3,4 or 5 substituting group, described substituting group to can be identical or different and independently be selected from;

    Deuterium, halogen, cyano group, alkyl, hydroxyalkyl, cyano group alkyl, haloalkyl, thiazolinyl, alkynyl, alkoxyl group, alkyl alkoxy, halogenated alkoxy, aryloxy ,-NR aR b,-CONR aR b,-S (O) 2-alkyl ,-S (O) 2-aryl ,-S (O) 2N (alkyl) 2,-S (O) 2-CF 3,-C (O) alkyl ,-NH-C (O) alkyl ,-NH-C (O) aryl, methylene-dioxy ,-(CH 2) qCycloalkyl ,-(CH 2) qAryl ,-(CH 2) qHeteroaryl and-(CH 2) qHeterocyclylalkyl, (ii) in addition, each in wherein said cycloalkyl, aryl, Heterocyclylalkyl and the heteroaryl can be unsubstituted or by one or more halogen, cyano group, alkyl or alkoxyl group replaces or can with independent aryl, heteroaryl, the Heterocyclylalkyl of selecting or Cycloalkylfused;

    R aAnd R bBe independently H, alkyl, alkoxyl group, aryl, alkoxyalkyl ,-S (O) 2Alkyl and cycloalkyl or R aAnd R bCan form 5 yuan or 6 yuan of Heterocyclylalkyls with the nitrogen-atoms that they connect, wherein said Heterocyclylalkyl can contain one or more other heteroatoms that is selected from N, S or O;

    R 2And R 3Be H or deuterium;

    M, n, p and q are 0,1 or 2 independently.

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