Liraglutide preparation method

Liraglutide preparation method

  • CN 103,275,209 A
  • Filed: 05/27/2013
  • Published: 09/04/2013
  • Est. Priority Date: 05/27/2013
  • Status: Active Application
First Claim
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1. prepare the method for Li Lalu peptide, comprising:

  • GLP1 (7-37) the peptide section of N end protection under the effect of alkali with N α

    Linked reaction takes place in-PAL-γ

    -Glu (OtBu)-ONSu, obtains Li Lalu peptide protection peptide;

    Li Lalu peptide protection peptide obtains Li Lalu peptide crude product after going the protection of N end after acidolysis;

    Li Lalu peptide purifying crude is got profit and is drawn the pure product of Shandong peptide;

    Described GLP1 (7-37) peptide section sequence is;


    Wherein R is Fmoc, Dde or ivDde.

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