For the composition of the chemoembolization of solid tumor

For the composition of the chemoembolization of solid tumor

  • CN 103,393,605 B
  • Filed: 02/12/2004
  • Issued: 05/29/2018
  • Est. Priority Date: 02/12/2003
  • Status: Active Grant
First Claim
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1. a kind of composition, said composition includes, and there is a kind of chance water may expand but polymer substrate not soluble in water and a kind of suctionIt is received in the particle of the water-soluble therapeutic agents in the matrix, it is characterised in that:

  • The polymer is in the range of pH6-8 totally with negativeCharge, when the particle expands in water reaches balance, particle size is between 40-1500 μ

    m, and the therapeutic agent is extremelyFew band there are one amino anthracycline compound, wherein anion level in the polymer substrate 0.1-10meq/g itBetween, the polymer includes crosslinked polyvinyl alcohol, and the particle is microballoon;

    Said composition by each molecule contain at least two ethylene linkage unsaturated terminal chain groups polyvinyl alcohol macromonomer andEthylene linkage unsaturated monomer combined polymerization including anionic monomer is formed;

    Wherein described polyvinyl alcohol macromonomer is carried by providing with the molecular weight between 1000-500,000 daltonThe polyvinyl alcohol polymer of ethylene or acrylic acid side-chain radical is made;

    And the weight ratio of wherein described polyvinyl alcohol macromonomer and other monomers is in the range of 50;

    1 to 1;

    5;

    In ethylene linkageIn unsaturated monomer, the content of anionic monomer is in 10-100 moles of % scope.

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