The oligodendroglia of myelinization again and the treatment for spinal cord injury of derived from primate embryonic stem cells

The oligodendroglia of myelinization again and the treatment for spinal cord injury of derived from primate embryonic stem cells

  • CN 103,396,993 B
  • Filed: 07/11/2003
  • Issued: 12/07/2018
  • Est. Priority Date: 07/11/2002
  • Status: Active Grant
First Claim
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1. the first cell mass and the second cell mass, it includes:

  • A) the first cell mass, it includes the ligands in the ligand comprising mitogen, Thyroid Hormone Receptors and retinoic acid receptorsCulture medium in undifferentiated primate multipotency do having been established for (pPS) cell be, wherein it is described oneself establish system do not includeIt directly decomposes from Human embryo or the pPS cell or embryonic stem cell of blastocyst;

    WithB) the second cell mass, it includes the cell mass of differentiation, the cell mass of the differentiation is the body of oligodendrocyte precursorsOuter offspring, which is that the external offspring for being has been established in the undifferentiated pPS cell, wherein describedAt least 80% cell is dyed by the antibody to NG2 proteoglycans specificity and is in neuron marker in the cell mass of differentiationNeuN is negative;

    And at least 10% cell has the complicated protrusion of mature oligodendroglia in the cell mass of the differentiation.

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