For treating the control release corticosteroid composition and method of otic conditions

For treating the control release corticosteroid composition and method of otic conditions

  • CN 103,417,472 B
  • Filed: 05/14/2009
  • Issued: 01/02/2018
  • Est. Priority Date: 05/14/2008
  • Status: Active Grant
First Claim
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1. a kind of be suitable for by being administered in tympanum on or near ear round window membrane to treat the medical thermal reversion of otic conditionsProperty gel combination, it is included:

  • 4.5wt% is to more particle dexamethasone between 6wt%;

    14wt% is to the poloxamer between 17wt%;

    WithWater,The pH value of wherein described composition is 7.0-7.8, osmolality 270-320mOsm/kg, and gelation temperatureFor 20-30 DEG C, and wherein described composition provides the dexamethasone of the therapeutically effective amount after single administering into inner ear at least 5The sustained release of it time.

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