Hypromellose enteric empty capsule gelated by gellan gum and calcium chloride

Hypromellose enteric empty capsule gelated by gellan gum and calcium chloride

CN
  • CN 103,417,511 B
  • Filed: 08/11/2013
  • Issued: 06/10/2015
  • Est. Priority Date: 08/11/2013
  • Status: Active Grant
First Claim
Patent Images

1. , by the hypromellose enteric hollow capsule of carrageenan and calcium chloride gel, it is characterized in that preparation method is as follows:

  • (1) get hypromellose 50kg, putting into 165-175L temperature is in the purified water of 77-83 DEG C, constantly stirs by the mixing speed of 1550-1650rpm and naturally cools to 22-28 DEG C, and then insulation leaves standstill 60-90min, again solution is heated to 35-45 DEG C, obtains hypromellose cellulose solution;

    (2) getting carrageenan 200g-210g, to be dissolved in 19-21L temperature be in the purified water of 35-45 DEG C, 3-5min is stirred by the speed of 2550-2650rpm, join in hypromellose cellulose solution until completely dissolved, the speed of continuation 1550-1650rpm stirs 2-3min, mix homogeneously;

    (3) getting calcium chloride 270-280g joins in hypromellose cellulose solution, the speed of continuation 1550-1650rpm stirs and naturally cools to 22-28 DEG C, again solution is heated to 35-45 DEG C after leaving standstill 2-3min, then insulation leaves standstill 60-120min, obtain flooding stable colloidal solution, then dip in glue Cheng Mo, then drying obtains dry capsule rod under 30-35 DEG C of room temperature;

    (4) capsule rod is immersed in Hydroxypropyl methyl cellulose phtalate organic solution, then take out drying;

    (5), finally by the demoulding, cutting, fit, makes hypromellose enteric hollow capsule.

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