Hypromellose enteric empty capsule gelated by gellan gum and potassium chloride

Hypromellose enteric empty capsule gelated by gellan gum and potassium chloride

CN
  • CN 103,417,979 A
  • Filed: 08/11/2013
  • Published: 12/04/2013
  • Est. Priority Date: 08/11/2013
  • Status: Active Grant
First Claim
Patent Images

1. by the hypromellose enteric hollow capsule of gellan gum and potassium chloride gel, it is characterized in that preparation method is as follows:

  • (1) get hypromellose 50kg, in the purified water that to put into the 165-175L temperature be 80-100 ℃

    , by the mixing speed of 1550-1650rpm, constantly stir and naturally cool to 22-28 ℃

    , then be incubated standing 60-90min, again solution is heated to 40-45 ℃

    , obtains hypromellose solution;

    (2) getting gellan gum 300-350g is dissolved in the purified water that the 15-20L temperature is 40-45 ℃

    , stir 3-5min by the speed of 2550-2650rpm, join until completely dissolved in hypromellose solution, continue to stir 2-3min, mix homogeneously by the speed of 1550-1650rpm;

    (3) potassium chloride 280-300g joins in hypromellose solution, continue to stir and naturally cool to 22-28 ℃

    by the speed of 1550-1650rpm, again solution is heated to 40-45 ℃

    after standing 2-3min, then be incubated standing 60-120min, obtain flooding stable colloidal solution, then dip in glue Cheng Mo, then drying obtains dry capsule rod under 30-35 ℃

    of room temperature;

    (4) the capsule rod is immersed in hypromellose phthalic acid fat organic solution, then take out dry;

    (5) finally by the demoulding, cut, fit, make the hypromellose enteric hollow capsule.

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