FcgRIIb-specific Fc antibody

FcgRIIb-specific Fc antibody

  • CN 103,492,565 A
  • Filed: 02/24/2012
  • Published: 01/01/2014
  • Est. Priority Date: 02/25/2011
  • Status: Active Grant
First Claim
Patent Images

1. polypeptide, this polypeptide is the polypeptide variants that contains the antibody Fc district that at least one amino acid changes, wherein, this polypeptide is compared with parent'"'"'s polypeptide, with in conjunction with activity, the maintaining or reduce of Fc γ

  • RIIa (R type) and Fc γ

    RIIa (H type), with Fc γ

    RIIb in conjunction with increased activity, and the value of [the KD value of polypeptide variants to Fc γ

    RIIa (R type)]/[the KD value of polypeptide variants to Fc γ

    RIIb] is more than 1.2.

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