Compstatin and analogs thereof for eye disorders

Compstatin and analogs thereof for eye disorders

  • CN 103,505,718 B
  • Filed: 10/06/2006
  • Issued: 11/23/2018
  • Est. Priority Date: 10/08/2005
  • Status: Active Grant
First Claim
Patent Images

1. a kind of purposes of composition in the drug for preparing the age-related macular degeneration (ARMD) for treating subject,The subject has or easily development grain film new vessels, the composition include a effective amount of comp statin analog,Wherein the comp statin analog is the compound comprising cyclic peptide, and the cyclic peptide has Xaal-Cys-Val-Xaa2-Gln–

  • Asp–

    Xaa2*–

    Gly–

    Xaa3–

    His–

    Arg–

    Cys–

    Xaa4(SEQ ID NO;

    6) sequence,WhereinXaa1 be I1e, Val, Leu, B1-Ile, B1-Val, B1-Leu or the dipeptides comprising Gly-Ile or B1-Gly-Ile, andAnd B1 represents the first blocking part;

    Xaa2 be selected from Trp and Trp analog, Trp analog be selected from 2- naphthylalanine, 1- naphthylalanine, 2- indanyl glycine,β

    -3- benzothienyl-l-Alanine, 4- benzoyl phenylalanine, 1- methyl tryptophan, 5-methyl tryptophan and 5- fluorine colorPropylhomoserin;

    Xaa2* is Trp or 5- fluorotryptophan;

    Xaa3 is His, Ala or 2-amino-butyric acid;

    Xaa4 is L-Thr, D-Thr or the tripeptides comprising Thr-Ala-Asn, wherein carboxylic any in L-Thr, D-Thr or AsnBase end-OH is optionally substituted by the second blocking part B2;

    AndTwo Cys residues are connected by disulfide bond.

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