Maleate salts of (e)-n-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof

Maleate salts of (e)-n-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof

  • CN 103,554,086 A
  • Filed: 10/16/2008
  • Published: 02/05/2014
  • Est. Priority Date: 10/17/2007
  • Status: Active Application
First Claim
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1. preparation is as the chloro-4-of (E)-N-{4-[3-(the 2-pyridyl methoxyl group) anilino of maleate]-3-cyano group-7-oxyethyl group-6-quinolyl } method of-4-(dimethylamino)-2-butylene acid amides, comprise the following steps:

  • by the chloro-4-of (E)-N-{4-[3-(2-pyridyl methoxyl group) anilino]-3-cyano group-7-oxyethyl group-6-quinolyl-4-(dimethylamino)-2-butylene acid amides and toxilic acid mix in the water-alcohol solution of high temperature.

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