Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions

Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions

  • CN 103,555,733 A
  • Filed: 01/05/2006
  • Published: 02/05/2014
  • Est. Priority Date: 01/05/2005
  • Status: Active Application
First Claim
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1. for the method for engineering immunoglobulins, the combination of described immunoglobulin (Ig) to epitope modified and measured at least one place being included in the structure ring region of described immunoglobulin (Ig), wherein the immunoglobulin (Ig) of unmodified is not significantly in conjunction with described epi-position, and described method comprises the following steps:

  • -the nucleic acid that provides encoded packets to contain the immunoglobulin (Ig) at least one structure ring region,-modify at least one nucleotide residue in structure ring region described at least one,-described modified nucleic acid is transferred to expression system,-express described modified immunoglobulin (Ig),-the modified immunoglobulin (Ig) of expressing is contacted with epi-position, and-whether measure described modified immunoglobulin (Ig) in conjunction with described epi-position.

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