Dual variable region antibody-like binding proteins having cross-over binding region orientation

Dual variable region antibody-like binding proteins having cross-over binding region orientation

  • CN 103,562,221 A
  • Filed: 03/28/2012
  • Published: 02/05/2014
  • Est. Priority Date: 03/28/2011
  • Status: Active Grant
First Claim
Patent Images

1. comprise the antibody sample of 4 polypeptide chains that form 4 antigen binding sites in conjunction with an albumen, wherein 2 polypeptide chains have the structure being expressed from the next:

  • V L1-L 1-V L2-L 2-C L [I] And 2 polypeptide chain has the structure being expressed from the next;

    V H2-L 3-V H1-L 4-C H1-Fc [II] Wherein;

    V l1it is the first immunoglobulin light chain variable structural domain;

    V l2it is the second immunoglobulin light chain variable structural domain;

    V h1it is the first immunoglobulin heavy chain variable structural domain;

    V h2it is the second immunoglobulin heavy chain variable structural domain;

    C lfor immunoglobulin light chain constant structural domain;

    C h1for immunoglobulin (Ig) C h1heavy chain constant domain;

    Fc is immunoglobulin hinge region and C h2, C h3heavy chain immunoglobulin constant domain;

    With L 1, L 2, L 3and L 4for amino acid joint;

    And the polypeptide of its Chinese style I and the polypeptide of formula II form exchange light chain-heavy chain pair.

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