Nucleic acid

Nucleic acid

  • CN 103,667,304 B
  • Filed: 03/28/2008
  • Issued: 02/02/2018
  • Est. Priority Date: 03/28/2007
  • Status: Active Grant
First Claim
Patent Images

1. a kind of nucleic acid, the nucleic acid includes the sequence for recombinating heavy chain of (a) promoter, (b) encoding leader sequence and antibody, and(c) sequence of the light chain of encoding antibody, whereinThe heavy chain has at least one heterologous T cell epitope, the heterologous T cell epitope destroy the heavy chain so thatThe heavy chain can not take its native conformation can not to be associated with antibody light chain when the nucleic acid is expressed,At least one heterogeneous cell T lymphocyte epitopes are located in the CDRH1 and/or CDRH2 of the heavy chain of the antibody,At least one heterologous helper T cell epitope is located in the light chain of the antibody or in the heavy chain of the antibody,AndThe promoter (i) causes the nucleic acid to exist for cell therein that be activated of expressing without specificity, or (ii)Expression in dendritic cells.

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