Method for determining content and impurity limit of imatinib mesylate based on HPLC-DAD (High performance liquid chromatography-diode array detection) method

Method for determining content and impurity limit of imatinib mesylate based on HPLC-DAD (High performance liquid chromatography-diode array detection) method

  • CN 103,852,544 A
  • Filed: 11/21/2013
  • Published: 06/11/2014
  • Est. Priority Date: 11/21/2013
  • Status: Active Application
First Claim
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1. measure the method for imatinib mesylate content and l.o.i thereof based on HPLC-DAD method for one kind, it is characterized in that adopting C18 chromatographic column, take methyl alcohol-triethylamine aqueous solution as mobile phase, the concentration expressed in percentage by volume of described triethylamine aqueous solution is that 0.5%~

  • 1%, pH value is 7.5~

    11;

    Gradient elution, flow velocity is 0.8~

    1.2mL/min, detection wavelength is 200~

    400nm;

    The program of described gradient elution is 0~

    55min, 65% →

    15% triethylamine aqueous solution.

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