Compstatin analogs with improved pharmacokinetic properties

Compstatin analogs with improved pharmacokinetic properties

  • CN 103,987,725 A
  • Filed: 09/07/2012
  • Published: 08/13/2014
  • Est. Priority Date: 09/07/2011
  • Status: Active Application
First Claim
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1. one kind comprises modified compstatin peptide (ICVVQDWGHHRCT (ring C2-C12;

  • SEQ ID NO;

    1) or the compound of its analogue, wherein said modification comprises described in N-terminal component interpolation or that replace that component has been improved C3, C3b or the C3c binding affinity of (1) described peptide compared to the unmodified compstatin peptide under condition of equivalent, (2) solubleness of described peptide in liquid, aqueous, and/or the plasma stability of (3) described peptide and/or the blood plasma residence time.

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