Compstatin analogs with improved pharmacokinetic property

Compstatin analogs with improved pharmacokinetic property

  • CN 103,987,725 B
  • Filed: 09/07/2012
  • Issued: 04/16/2019
  • Est. Priority Date: 09/07/2011
  • Status: Active Grant
First Claim
Patent Images

1. a kind of compound comprising modified compstatin peptide, wherein the sequence of the modified compstatin peptide is such asSEQ ID NO:

  • 7,SEQ ID NO;

    8,SEQ ID NO;

    9,SEQ ID NO;

    10,SEQ ID NO;

    11,SEQ ID NO;

    13,SEQ ID NO;

    14,SEQ ID NO;

    15,SEQ ID NO;

    18,SEQ ID NO;

    19,SEQ ID NO;

    20,SEQ ID NO;

    Shown in 21, SEQ ID NO;

    23, SEQ ID NO;

    25 or SEQ ID NO;

    27, it is described modification include addition N-terminal component orSubstituted N-terminal component, the component is compared to improving (1) described peptide for the unmodified compstatin peptide under condition of equivalentC3, C3b or C3c binding affinity, solubility of (2) the described peptide in liquid, aqueous, and/or the blood plasma of (3) described peptide is steadyThe qualitative and/or blood plasma residence time.

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