Replication-defective arenavirus vectors

Replication-defective arenavirus vectors

  • CN 103,993,012 A
  • Filed: 12/22/2008
  • Published: 08/20/2014
  • Est. Priority Date: 12/27/2007
  • Status: Active Application
First Claim
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1. the arenavirus genome of the infectious arenavirus particle of replication defect type, it can increase and expresses its genetic information but can not in non-covering cell, further produce infectious progeny particle in the cell being infected by described virion, wherein, in described arenavirus genome, at least one in four arenavirus open reading frame of coding glycoprotein (GP), nucleoprotein (NP), stromatin Z and RNA RNA-dependent polysaccharase L is removed or inactivation in function.

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