New antibodies against phosphorylcholine

New antibodies against phosphorylcholine

  • CN 104,039,832 A
  • Filed: 08/08/2012
  • Published: 09/10/2014
  • Est. Priority Date: 08/09/2011
  • Status: Active Application
First Claim
Patent Images

1. can be in conjunction with antibody or an antibody fragment for Phosphorylcholine and/or Phosphorylcholine binding substances, wherein antibody or antibody fragment comprise weight chain variable (VH) region and/or light chain variable (VL) region, and wherein:

  • (a) VH region comprises aminoacid sequence, and this aminoacid sequence comprises 1,2 or 3 and is selected from following complementary determining region (CDR);

    CDR1 sequence, it comprises the aminoacid sequence with the sequence of SEQ ID NO;

    17 with at least 25%, 50%, 75% or 100% sequence identity;

    CDR2 sequence, it comprises the aminoacid sequence with the sequence of SEQ ID NO;

    18 with at least 5%, 11%, 17%, 23%, 29%, 35%, 47%, 52%, 58%, 64%, 70%, 76%, 82%, 94% or 100% sequence identity;

    WithCDR3 sequence, it comprises the aminoacid sequence with SEQ ID NO;

    19,20,21 or 22 sequence with at least 4%, 9%, 13%, 18%, 22%, 27%, 31%, 36%, 40%, 45%, 50%, 54%, 59%, 63%, 68%, 72%, 77%, 81%, 86%, 90%, 95% or 100% sequence identity;

    And/or(b) VL region comprises aminoacid sequence, and this aminoacid sequence comprises 1,2 or 3 and is selected from following complementary determining region (CDR);

    CDR4 sequence, it comprises the aminoacid sequence with the sequence of SEQ ID NO;

    23 or 24 with at least 5%, 11%, 17%, 23%, 29%, 35%, 47%, 52%, 58%, 64%, 70%, 76%, 82%, 94% or 100% sequence identity;

    CDR5 sequence, it comprises the aminoacid sequence with the sequence of SEQ ID NO;

    25 with at least 14%, 28%, 42%, 57%, 71%, 85% or 100% sequence identity;

    CDR6 sequence, it comprises the aminoacid sequence with the sequence of SEQ ID NO;

    26 with at least 11%, 22%, 33%, 44%, 55%, 66%, 77%, 88% or 100% sequence identity.

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