Synthetic method of harringtonine C-ring intermediate

Synthetic method of harringtonine C-ring intermediate

  • CN 104,045,645 A
  • Filed: 05/26/2014
  • Published: 09/17/2014
  • Est. Priority Date: 05/26/2014
  • Status: Active Application
First Claim
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1. One kind with 3,4-methylene-dioxy phenylethylamine for raw material, the method for synthetic harringtonine C ring intermediate, its reaction process comprises following three steps:

  • Step (1);

    amido protecting and N-H bond activation step;

    with 3,4-methylene-dioxy phenylethylamine I, for raw material, under alkaline condition, generate intermediate N acyl group-3 of nitrogen end protection with acylation reaction, 4-methylene-dioxy phenylethylamine II, its general formula is expressed as;

    or be

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