The synthetic method of harringtonine C ring intermediates

The synthetic method of harringtonine C ring intermediates

  • CN 104,045,645 B
  • Filed: 05/26/2014
  • Issued: 10/19/2018
  • Est. Priority Date: 05/26/2014
  • Status: Active Grant
First Claim
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1. one kind is with 3,4- methylene-dioxy phenyl ethylamines for raw material, the method for synthesizing harringtonine C ring intermediates was reactedJourney includes following three steps:

  • Step (1):

    Amido protecting and N-H bond activation steps:

    With 3,4- methylene-dioxies phenyl ethylamine I for raw material, in alkaline conditionLower and acylation reaction generates intermediate N acyl group -3,4- methylene-dioxy phenyl ethylamine II of nitrogen end protection, and general formula is expressed as:

    Or it is

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