Interleukin 37 containing drug, preparation method and application thereof

Interleukin 37 containing drug, preparation method and application thereof

  • CN 104,083,755 A
  • Filed: 11/21/2013
  • Published: 10/08/2014
  • Est. Priority Date: 11/21/2013
  • Status: Active Application
First Claim
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1. a medicine that is used for the treatment of autoimmune or chronic noninfective inflammation disease, is characterized in that, described medicine is taking interleukin Ⅲ

  • 7, its derivant, variant and/or truncate polypeptide as active component;

    Optionally, also comprise pharmaceutically acceptable carrier;

    Preferably, described interleukin Ⅲ

    7 has the aminoacid sequence as shown in SEQ ID NO;

    1;

    Preferably, described derivant is that aminoacid sequence as shown in SEQ ID NO;

    1 replaces, lacks and/or insert one or more aminoacid and have and the aminoacid sequence of the same or similar activity of aminoacid sequence shown in SEQ ID NO;

    1;

    Preferably, described variant is that interleukin Ⅲ

    7 or derivatives thereofs connect sugar and/or fatty PEG modifies function and the same or analogous modified peptides of interleukin Ⅲ

    7 that side chain obtains;

    Preferably, described truncate polypeptide is the truncate polypeptide comprising as the active fragment of partial amino-acid series in SEQ ID NO;

    1;

    Preferably, described disease comprises rheumatoid arthritis, systemic lupus erythematosus (sle), atopic dermatitis, psoriasis, Crohn disease, multiple sclerosis, asthma, diabetes, transplant rejection, atherosclerosis, inflammatory bowel disease, ankylosing spondylitis, hyperthyroidism, hashimoto'"'"'s thyroiditis or aplastic anemia.

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