Steroid 5-alpha-reductase inhibitors

Steroid 5-alpha-reductase inhibitors

  • CN 1,041,054 C
  • Filed: 02/13/1993
  • Issued: 12/09/1998
  • Est. Priority Date: 04/29/1987
  • Status: Active Grant
First Claim
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1. preparation contains the method for the pharmaceutical composition of the inhibition 5-5 alpha-reductases of formula V compound or pharmaceutically acceptable salt thereof down, Wherein the A ring is up to two two keys and is represented by dotted line in the formula, B and C ring can select to have two keys, and shown in middle dotted line, condition is, when the A ring has C 4-C 5Or C 5-C 10During two key, the B ring does not just have two keys;

  • X is hydrogen or fluorine,Y is hydrogen, trifluoromethyl or fluorine,R 1Do not exist or hydrogen or methyl, condition is when on the carbon that is attached thereto two key being arranged, R 1Do not exist, R 2Do not exist or α

    -hydrogen, condition is when it is adjacent with a pair of key, R 2Do not exist, R 3Be (a) CH (CH 3) CH 2OH, or (b) CONR 4R 5, R wherein 4With R 5Be selected from hydrogen, isopropyl or the tert-butyl group separately, R is hydrogen or methyl;

    Said composition contains above-listed formula V chemical compound and pharmaceutically acceptable carrier, and described method comprises formula V chemical compound and described carrier admixed together.

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