Fusion protein containing leucine-rich repetitive sequence, and preparation method and application thereof

Fusion protein containing leucine-rich repetitive sequence, and preparation method and application thereof

  • CN 104,119,448 A
  • Filed: 04/26/2013
  • Published: 10/29/2014
  • Est. Priority Date: 04/26/2013
  • Status: Active Application
First Claim
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1. a fusion rotein, is characterized in that, described fusion rotein is held to C end and had the structure described in formula Ia or Ib from N:

  • A-X-E-Y1-Y2 formula Ia;

    A-Y2-Y1-E-X formula Ib;

    Wherein,A is optional secreting signal peptide;

    X is the leucic tumor-necrosis factor glycoproteins 2 of being rich in of Slit3 albumen (leucine-rich repeat2, LRR2) element;

    E is restriction enzyme site;

    Y1 is the first label polypeptide element;

    Y2 is the second label small peptide element, and described the second label small peptide element is His label element;

    "-" represents to connect peptide bond or the peptide linker of said elements.

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