Targeting interferon-lambda with antibodies potently enhances anti-tumor and anti-viral activities

Targeting interferon-lambda with antibodies potently enhances anti-tumor and anti-viral activities

  • CN 104,159,600 A
  • Filed: 01/25/2013
  • Published: 11/19/2014
  • Est. Priority Date: 01/26/2012
  • Status: Active Application
First Claim
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1. a method for the treatment of cancer, viral infection, asthma or multiple sclerosis, it comprises:

  • A) obtain interferon-antibody complex, it comprises;

    I) the first fusion rotein, interferon-λ

    that it comprises anchoring structure territory (AD) part that is connected to AKAP protein;

    Ii) the second fusion rotein, it comprises the dimerization that is connected to human kinase protein A (PKA) RI α

    , RI β

    , RII α

    or RII β and

    antibody or the antigen binding antibody fragment of stopping domain (DDD) part;

    AndB) to the experimenter with cancer, viral infection, asthma or multiple sclerosis, use described interferon-antibody complex;

    Wherein the described DDD of two copies partly forms dimer, and described dimer is incorporated into described AD part to form described complex.

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