Effectively strengthen antitumor and antiviral activity with antibody target interferon lambda

Effectively strengthen antitumor and antiviral activity with antibody target interferon lambda

  • CN 104,159,600 B
  • Filed: 01/25/2013
  • Issued: 04/10/2018
  • Est. Priority Date: 01/26/2012
  • Status: Active Grant
First Claim
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1. use of the interferon-antibody complex in the medicine for preparing treating cancer, virus infection, asthma or multiple sclerosisOn the way, it includes:

  • A) interferon-antibody complex is obtained, it is included:

    I) the first fusion protein, it includes the interferon-λ

    of anchoring domain (AD) part for being connected to AKAP protein;

    Ii) the second fusion protein, it includes and is connected to human kinase protein A (PKA) RI α

    , RI β

    , RII α

    or RII β

    dimerizationWith the antibody or antigen binding antibody fragment of dockerin domain (DDD) part;

    AndB) it is compound using the interferon-antibody to the subject with cancer, virus infection, asthma or multiple sclerosisThing;

    The DDD parts of two of which copy form dimer, and it is described to be formed that the dimer is incorporated into the AD partsCompound, andWherein described first fusion protein is SEQ ID NO:

    The modules of AD2-IFN- λ

    1 or SEQ ID NO shown in 96:

    Shown in 97AD2-IFN- λ

    1-C171S modules, second fusion protein is hRS7, hMN15, hL243, c225, alemtuzumab or rice are drawnThe Fab-DDD2 modules of pearl monoclonal antibody.

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