COMPOSITIONS AND SYSTEMS FOR FORMING CROSSLINKED BIOMATERIALS AND ASSOCIATED METHODS OF PREPARATION AND USE

COMPOSITIONS AND SYSTEMS FOR FORMING CROSSLINKED BIOMATERIALS AND ASSOCIATED METHODS OF PREPARATION AND USE

  • CN 104,174,071 A
  • Filed: 04/28/2005
  • Published: 12/03/2014
  • Est. Priority Date: 04/28/2004
  • Status: Active Application
First Claim
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1. a method that forms three dimensional matrix, comprises step:

  • (a) provide dry powder compositions, it comprises the first composition, it has the core being replaced by m nucleophilic group, wherein m >

    =2, and the second composition, it has the core being replaced by n electrophilic group, wherein n >

    =2 and m+n>

    4, and described nucleophilic and electrophilic group anergy in dry environment;

    (b) cause described nucleophilic and electrophilic group to have in aqueous environment reactive to react to each other to cause by exposing described compositions;

    Wherein said exposure comprises;

    (i) in the first buffer solution with 2.1 to 2.3 pH value scope, dissolve described compositions to form homogeneous phase solution, and(ii) to the second buffer solution that adds the pH value scope with 6.0 to 11.0 in described homogeneous phase solution;

    With(c) three-dimensional group compound is formed,Wherein said the first composition and described the second composition core are separately the polyalkylene oxides of branching, and described nucleophilic group is sulfydryl, and described electrophilic group is N-hydroxy-succinamide ester.

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