Antibody variants and uses thereof

Antibody variants and uses thereof

  • CN 104,220,093 A
  • Filed: 07/06/2012
  • Published: 12/17/2014
  • Est. Priority Date: 07/06/2011
  • Status: Active Grant
First Claim
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1. a raising comprises the method for the effector function of the parental polypeptide of immunoglobulin Fc territory and land, the method is included in parental polypeptide at least one amino acid residue be selected from corresponding to those amino acid residues of E345, E430, S440, Q386, P247, I253, S254, Q311, D/E356, T359, E382, Y436 and the K447 in human IgG1'"'"'s heavy chain Fc district and introduces sudden change, and condition is the sudden change in S440 is S440Y or S440W.

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