Single-stranded nucleic acid molecule for regulating expression of gene having delivering function

Single-stranded nucleic acid molecule for regulating expression of gene having delivering function

  • CN 104,379,744 A
  • Filed: 05/25/2013
  • Published: 02/25/2015
  • Est. Priority Date: 05/26/2012
  • Status: Active Application
First Claim
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1. a single stranded nucleic acid molecule, it is the expression inhibiting single stranded nucleic acid molecule of the target gene with delivery functions, described single stranded nucleic acid molecule is from 5 '"'"' side to 3 '"'"' side comprises 5 '"'"' side region (Xc), connexon region (Lx), interior region (Z), connexon region (Ly) and 3 '"'"' side region (Yc) in the following order, whereinAforementioned inner region (Z) is passed through the connection of inner 5 '"'"' side region (X) and inner 3 '"'"' side region (Y) and forms,Aforementioned 5 '"'"' side region (Xc) is complementary with aforementioned inner 5 '"'"' side region (X),Aforementioned 3 '"'"' side region (Yc) is complementary with aforementioned inner 3 '"'"' side region (Y),The expression inhibiting sequence one of at least comprising the expression suppressing target gene of aforementioned inner region (Z), aforementioned 5 '"'"' side region (Xc) and aforementioned 3 '"'"' side region (Yc), andWhat be selected from the group be made up of 5 '"'"' end, 3 '"'"' end, aforementioned connexon region (Lx) and aforementioned connexon region (Ly) one of is at least bonded to bio-related substance.

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