Skin cancer biomarker detection by infrared spectroscopy

Skin cancer biomarker detection by infrared spectroscopy

  • CN 104,394,758 A
  • Filed: 03/23/2013
  • Published: 03/04/2015
  • Est. Priority Date: 03/23/2012
  • Status: Active Application
First Claim
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1. detect the method that whether there are Molecular biomarkers bands of a spectrum in histopathology epidermis infrared spectrum, described histopathology epidermis from optimum, worsen before and worsen the relevant sample of cutaneous tumor cutaneous carcinoma tissue, comprising:

  • I () is to 700-4000cm -1in district, aminoacyl I (near 1650cm-1) carries out infrared spectrum normalized;

    (ii) baseline in finger print region is corrected, to eliminate the difference between spectrum;

    (iii) to 1055cm -1near the peak of multiplet carry out belonging to and to 1071,1084/1085 and 1095cm -1the all peaks detected in neighbouring DNA/RNA triplet belong to;

    (iv) 1055cm is determined -1the average peak position that moves to left or move to right of neighbouring multiplet, determines that shift to right or left changes in addition;

    V () calculates 1055cm -1near the meansigma methods of multiplet that belonged to;

    (vi) 1071cm is calculated -1, and/or 1084/1085cm -1and/or 1095cm -1the meansigma methods at the peak belonged in DNA/RNA triplet;

    (vii) calculating strength compares I 1055/ I 1245, wherein 1245cm -1neighbouring peak is the known peak of the combination of di-phosphate ester vibration (DNA) and amide III in infrared spectrum.

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