Method for expressing, secreting and transporting functional microRNA/siRNA and application thereof

Method for expressing, secreting and transporting functional microRNA/siRNA and application thereof

  • CN 104,411,339 B
  • Filed: 06/21/2013
  • Issued: 11/17/2020
  • Est. Priority Date: 06/21/2012
  • Status: Active Grant
First Claim
Patent Images

1. Use of a functional microRNA or an expression vector thereof for the preparation of a composition for injection into the common bile duct of a mammal, said composition forming cellular microparticles in a first site in the animal, said first site taking up said microRNA and re-secreting it in a cellular microparticle encapsulated form and being transported to a second site, wherein said second site is different from said first site, thereby treating colorectal cancer at said second site;

  • and, the first site is a liver;

    the second part is lymph and/or colorectal;

    and the functional microRNA is miR143 or miR 145.

View all claims
    ×
    ×

    Thank you for your feedback

    ×
    ×