Method for preparing compound aspirin double-layer tablet

Method for preparing compound aspirin double-layer tablet

  • CN 104,434,957 A
  • Filed: 12/16/2014
  • Published: 03/25/2015
  • Est. Priority Date: 12/16/2014
  • Status: Active Application
First Claim
Patent Images

1. prepare a method for magnalium department double-layer tablet, with 1000 with gauge, comprise the following steps:

  • 1) by aspirin 330g, tartaric acid 3.3g, low-substituted hydroxypropyl cellulose 8 ~ 15g, starch 30 ~ 40g and Pulvis Talci 12 ~ 18g mix homogeneously, put into tablet machine tabletting, obtain A sheet;

    2) after being dissolved by a small amount of purified water by lemon yellow 0.015 ~ 0.02g, add starch 4 ~ 8g, then add a small amount of purified water and stir evenly, then add purified water of boiling, continue to be stirred to ripe slurry, be mixed with 10% starch slurry;

    3) by Heavy Magnesium Carbonate 100g, dihydroxyaluminum aminoacetate 50g and starch 10 ~ 15g mix homogeneously, add step

         2) starch slurry, wet granulation, cross 16 mesh sieves granulate, drying obtains dry granule;

    4) by dry granule and Pulvis Talci 6 ~ 10g mix homogeneously, join step

         1) A sheet on, namely tabletting obtains double-layer tablet,Wherein, described step

         3) in drying, baking temperature is 60 DEG C ~ 70 DEG C, and after pellet moisture≤

    3%, temperature of blowing a cold wind over is down to 40 DEG C or following and is namely obtained dry granule.

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