Fresh agrimonia pilosa medicine preparation for treating wounds

Fresh agrimonia pilosa medicine preparation for treating wounds

  • CN 104,474,536 A
  • Filed: 11/19/2014
  • Published: 04/01/2015
  • Est. Priority Date: 11/19/2014
  • Status: Active Application
First Claim
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1. the present invention gets fresh Herba Agrimoniae Chinese medicine (Herba Agrimoniae Latin title:

  • same under Herba Agrimoniae), new pharmaceutical preparation is combined into the medicated powder after the processing of modern biotechnology preservation by low temperature and lysozyme (Latin title;

    Lysozyme, lower same).Technical solution of the present invention;

    One, raw material obtains;

    (this case mentions that fresh Herba Agrimoniae raw material takes from Hunan Province'"'"'s Ningxiang County and periphery region)Get fresh hairyvein agrimonia leaf, stem (can solely get or round strain) hereinafter referred to as " fresh Herba Agrimoniae ", first fresh Herba Agrimoniae sterile distilled water is cleaned up rear removal outside moisture (can use and dry device processes), fresh Herba Agrimoniae is sterilized (can also sterilize with the ethanol Quick disinfection of concentration less than 80% or by disinfectant such as mercuric chloride), within 1 hour total time of sterilization with ultraviolet radiation again.Two, processing method;

    1, fresh Herba Agrimoniae is processed into powder (wet-milling that water content is high, hereinafter referred to as " wet-milling ") by fresh Herba Agrimoniae room temperature to the temperature (available liquid nitrogen flash freezer) of-199 DEG C of scopes through cleaning and sterilizing.Wet-milling (or with the fresh Herba Agrimoniae through cleaning and sterilizing), (within 5-8 hour, effect is good to put into the lyophilization of freeze dryer evacuation again, general in 10 hours) make lyophilized powder (dry powder that water content is low, hereinafter referred to as " lyophilized powder ").The wet-milling high because of water content and the low lyophilized powder drug effect difference of water content little, so wet-milling and lyophilized powder are collectively referred to as " the fresh powder of Herba Agrimoniae ".Another;

    wet-milling uses freeze dryer lyophilizing after can adding quantitative lysozyme (within 0.05%-0.5%, effect is good, or with concentration within 3%) mixing, just can make freeze-dried powder preparation.2, by through cleaning and sterilizing fresh Herba Agrimoniae room temperature to the temperature equipment of-199 DEG C of scopes by fresh Herba Agrimoniae fragmentation after extract juice (also can be processed into lyophilized powder hereinafter referred to as " extracting solution " extracting solution).Three, formulation ingredients and synthetic technology schemeFormulation ingredients;

    Herba Agrimoniae fresh powder 97%-99.999%, lysozyme 0.001%-3% (lysozyme 0.05%-0.5% effect is good).Using two kinds of mixed medicines of composition in this preparation as traumatic wounds medication, can directly with or make patch (common name;

    adhesive bandage, lower with);

    Also can add other vaseline of pharmaceutical grade, glue or make preparation with media such as glycerol, or with the vaseline of medicinal rank, the medium such as glue or glycerol makes drug adhesion (or emulsifying) make patch on adhesive plaster (or ribbon);

    Also other low concentration sodium chloride solution of available pharmaceutical grade (the isotonic solution effect of 0.9% is good, also can by concentration within 9%), water is using medication after the damping of this preparation of Chinese medicine or as preparation.Medicine after the damping of this preparation can directly with or make patch;

    Also can add other vaseline of pharmaceutical grade, glue or make preparation with media such as glycerol, or with the vaseline of medicinal rank, the medium such as glue or glycerol makes drug adhesion (or emulsifying) make patch on adhesive plaster (or ribbon).Because fresh red crowned crane grass meal can be directly used in the hemostasis for the treatment of surgical wound wound, convergence, more wound, antiinflammatory, and instant effect, effective;

    So adding preservative agent, antibiotic medicine just can be combined into preparation.But general antiseptic or antibiotic medicine do not have the anticorrosion of lysozyme and antiinflammatory double effects;

    And antibiotic medicine and wound surface bond (Typical Representative;

    sulfonamides), inflammatory phenomena under crust can be formed.Nisin (Latin title;

    Nisin) solely can add or close with lysozyme and add (safety of Nisin and human body skin internal layer contact tissue under study for action).Illustrate;

    the effect by the damping of this preparation of Chinese medicine;

    the dry powder because of this preparation can absorb traumatic wounds and bleeds and produce condensation phenomenon, by medicine damping, this phenomenon can be alleviated, use wet medicated powder and wound wound surface generally non-caked (or it is few to bond), easily remove from wound surface with medicine later.Four, the advantage of Herba Agrimoniae fresh medicine preservation by low temperature processing method compared with Chinese medicine Preparation process method;

    Herba Agrimoniae fresh medicine preservation by low temperature processing method greatly improves reservation and the application of the active ingredient of Herba Agrimoniae fresh powder Chinese medicine, make the fresh powder of Herba Agrimoniae (wet-milling or lyophilized powder) through preservation by low temperature processing can be directly used in the hemostasis for the treatment of traumatic wounds, convergence, more wound, antiinflammatory, and instant effect, effective.And the hemostasis of the Herba Agrimoniae treated powder traumatic wounds of Chinese medicine Preparation process method processing, convergence, more creates DeGrain, is in dispute.Verify through zoopery;

    the fresh powder of Herba Agrimoniae is used for the treatment of wound mouth, within medication 2-3 hour, just obviously can observe the receipts sword of wound wound surface, drying effect, haemostatic effect is obvious, wound surface incrustation in 8-12 hour, totally, and general NIP phenomenon.And with Chinese medicine Preparation process method processing Herba Agrimoniae treated powder wound mouth, within 12 hours, all can not observe the receipts sword creating wound surface, drying effect, haemostatic effect is not obvious.Five, this preparation advantage1, simple, the safety of this pharmaceutical formulation composition, eliminates the use of toxic substance in the pharmaceutical preparation of traditional treatment traumatic wounds.2, the complete rear trace of this preparation for treating surgical wound wound is small, the outer wound of skin shallow-layer entirely heal (about 20 days) afterwards scar not easily discover (wound treatment of wounds whole process can not have iodine to remain, iodine is residual can cause wound mouth complete more after trace obvious).3, this preparation short wound wound surface self healing incrustation, short wound surface is dry, and medicated powder (damping) and wound surface be non-caked (or it is few to bond) generally, easily removes from wound surface with medicine later;

    Wound surface incrustation in the skin small size surgical wound 12 hours of movable joint place, and crust scar is not easily split, wound mouth not easy infection, inflammation phenomenon under general NIP and crust, well solves the difficult point of traditional traumatic wounds Drug therapy joint skin surgery the wound refused to heal.It is a kind of new drug with breakthrough therapeutic effect.4, two kinds of antimicrobial factorses combine, and reach broad-spectrum antiseptic anti-inflammatory effect.5, indicate;

    available (water preparation, composition the 6th describes in detail), as traumatic wounds process, as debridement, stops blooding;

    Use after traumatic wounds scabs.(water preparation) is as the composite reagent (treatment of wounds) of this preparation;

    Because (water preparation) is raw materials used the same with this preparation, the property of medicine is close, makes the trace of this preparation little, and the feature that bond with wound surface more obviously (and easily cause iodine residual with povidone iodine process wound, it is obvious that iodine remains meeting trace).(water preparation) and traditional vulnerary with the use of, its feature is difficult to embody separately.(water preparation) can divisional application by Patent Law detailed rules for the implementation 34 and 42 requirements.6, (water preparation composition);

    fresh Herba Agrimoniae extracting solution 1%-99.999%, lysozyme 0.001%-3% (lysozyme 0.05%-0.5% effect is good), distilled water 0%-99% (it is good that the sodium chloride that can add 0.9% makes isotonic solution effect, also can by concentration within 9%).Illustrate;

    this preparation tests medication in person through the present invention first, second inventor, sums up above advantage in conjunction with zoopery.Six, preparation explanationThe fresh powder of Herba Agrimoniae;

    hemostasis, convergence, more wound, antiinflammatory.Lysozyme;

    antiinflammatory, sterilization, fresh-keeping.This preparation be with the fresh powder of Chinese medicine Herba Agrimoniae for principal agent, add lysozyme mixing after, enhance anti-inflammatory (increase antibacterial range) and the stability (lysozyme has antisepsis) of preparation of Chinese medicine;

    The fresh powder of Herba Agrimoniae because of store and processing wants cold storing and fresh-keeping or freezen protective to ensure the stability of medicine, adds the fresh-keeping fresh powder stability of Herba Agrimoniae that makes of lysozyme and is strengthened.This preparation [function cures mainly] stops blooding, antiinflammatory, convergence, more wound.Seven, the scope of request protection1, the fresh powder 97%-99.999% of Herba Agrimoniae, lysozyme 0.001%-3%, is combined into preparation.2, with;

    the fresh powder 97%-99.999% of Herba Agrimoniae, lysozyme 0.001%-3%, be combined into preparation for principal agent adds other adjuvant (as other vaseline of pharmaceutical grade, glue, glycerol, water, low concentration sodium chloride solution, adhesive plaster etc.).3, with the fresh powder 97%-99.999% of Herba Agrimoniae, lysozyme 0.001%-3%, for principal agent add other adjuvant (as other vaseline of pharmaceutical grade, glue, glycerol, water, low concentration sodium chloride solution, adhesive plaster, antibiotic medicine, other type antiseptic etc.) be combined into preparation.4, the fresh powder 94%-99.999% of Herba Agrimoniae, singly adds nisin (Latin title;

    Nisin) 0.001%-3% or share with lysozyme 0.001%-3%;

    Other adjuvant (as other vaseline of pharmaceutical grade, glue, glycerol, water, low concentration sodium chloride solution, adhesive plaster etc.) can be added and be combined into preparation.5, the fresh powder of Herba Agrimoniae adds the antiseptic of other type, antibiotic medicine;

    Other adjuvant (as other vaseline of pharmaceutical grade, glue, glycerol, water, low concentration sodium chloride solution, adhesive plaster etc.) can be added and be combined into preparation.6, the fresh powder of Herba Agrimoniae adds adjuvant (as other vaseline of pharmaceutical grade, glue, glycerol, water, low concentration sodium chloride solution, adhesive plaster etc.) and is combined into preparation.7, the fresh powder of Herba Agrimoniae is as pharmaceutical preparation.8, can the water preparation of divisional application with fresh Herba Agrimoniae extracting solution 1%-99.999%, lysozyme 0.001%-3% (the antiseptic of other type available or alone, antibiotic medicine), sterile distilled water 0%-99%, (within can adding low concentration sodium chloride 0.9% or 9%) is combined into preparation.

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