Composition and methods for highly efficient gene transfer using AAV capsid variants

Composition and methods for highly efficient gene transfer using AAV capsid variants

  • CN 104,487,579 A
  • Filed: 04/18/2013
  • Published: 04/01/2015
  • Est. Priority Date: 04/18/2012
  • Status: Active Application
First Claim
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1. adeno-associated virus (AAV) carrier improved, described carrier comprises VP1 capsid protein, described VP1 capsid protein comprises one or more Methionin and replaces, described carrier also comprises minigene, described minigene comprises the AAV oppositely terminal repetition heterologous nucleic acid sequence with being operationally connected to regulating and controlling sequence, described regulating and controlling sequence guides in host cell by the expression of described heterologous nucleic acid sequence to product, the ubiquitination that described Methionin is replaced for the described capsid protein of suppression is effective, increases described AAV carrier thus to the transduction in target cell.

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