A method for preparing cyclocarya paliurus extract with antioxidant activity and its application as aldose reductase inhibitor

A method for preparing cyclocarya paliurus extract with antioxidant activity and its application as aldose reductase inhibitor

  • CN 104,490,993 B
  • Filed: 01/16/2015
  • Issued: 09/15/2020
  • Est. Priority Date: 01/16/2015
  • Status: Active Grant
First Claim
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1. The application of the cyclocarya paliurus extract with antioxidant activity in preparing aldose reductase inhibitors is characterized in that the cyclocarya paliurus extract is obtained by the following steps:

  • (1) crushing;

    drying cyclocarya paliurus leaves at 75 ℃

    , crushing by a crusher, and sieving by a 40-mesh sieve;

    (2) soaking;

    soaking the medicinal materials in water for 14h according to the weight ratio of the medicinal materials to the water of 1;

    20;

    (3) extraction;

    carrying out ultrasonic treatment on the mixed solution in the step (2) at 600W for 40 minutes at the temperature of 50 ℃

    ;

    filtering with four layers of 200 mesh filter cloth while hot, vacuum filtering with Buchner funnel, collecting filtrate, decolorizing with 1% -3% active carbon, and concentrating under reduced pressure;

    concentrating under-0.09 MPa and 70 deg.C to original volume of 1/10;

    (4) and (3) freeze drying;

    freeze-drying at-25 deg.C and-0.01 kPa to obtain brown powder, i.e. the cyclocarya paliurus extract with antioxidant activity;

    wherein the aldose reductase inhibitor is used for preventing and treating diabetic complications.

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