Controlled Release Antimicrobial Compositions And Methods For The Treatment Of Otic Disorders

Controlled Release Antimicrobial Compositions And Methods For The Treatment Of Otic Disorders

  • CN 104,491,864 A
  • Filed: 04/21/2009
  • Published: 04/08/2015
  • Est. Priority Date: 04/21/2008
  • Status: Active Application
First Claim
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1. a pharmaceutical formulation, it is used for the treatment of ear disease or the patient'"'"'s condition, and it is through allotment to provide the immunomodulator for the treatment of effective dose, and described composite comprises:

  • Immunomodulator between about 0.2 % by weight and about 6 % by weight, orIts pharmaceutically acceptable prodrug or salt;

    The PULLRONIC F68 triblock copolymer of the general formula E 106 P70 E106 between about 16 % by weight and about 21 % by weight;

    Enough sterilized water, its through buffering to provide between about 6.0 and to be suitable for perilymphatic pH value about between 7.6;

    With a small amount of in fact catabolite of described immunomodulator;

    Wherein said pharmaceutical formulation has between being suitable for perilymphatic capacity osmotic pressure about between 250mOsm/L and 320mOsm/L,Be less than the anti-microbial agent/gram composite of about 50 colony-forming units (cfu), andBe less than about 5 endotoxin unit (EU)/kg whose body weights.

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