Asymmetric catalytic method of enamine compounds

Asymmetric catalytic method of enamine compounds

  • CN 104,496,735 A
  • Filed: 01/06/2015
  • Published: 04/08/2015
  • Est. Priority Date: 01/06/2015
  • Status: Active Application
First Claim
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1. the asymmetric hydrogenation method of a fluorine-containing olefinic amine compound, it is characterized in that, under comprising the steps:

  • anhydrous and oxygen-free condition, by mol ratio be 1;

    0.8 ~ 1.2 rhodium catalyst and chiral ligand be together dissolved in solvent orange 2 A, at 20 DEG C ~ 40 DEG C, stirring reaction 0.5 ~ 2 hour, namely obtains situ catalytic agent;

    Situ catalytic agent is not separated separately, directly adds olefinic amine compound and solvent B, forming reactions system;

    Reaction system is placed in autoclave, at 0 ~ 50 DEG C, 2 ~ 50atm H 2stirring reaction 2 ~ 24 hours under condition;

    Described rhodium catalyst is two (1,5-cyclooctadiene) Tetrafluoroboric acid rhodiums or two (norbornadiene) Tetrafluoroboric acid rhodium;

    Described chiral ligand is Described solvent orange 2 A is the one in methyl alcohol, ethanol, Virahol, trifluoroethanol, ethyl acetate, methylene dichloride, Isosorbide-5-Nitrae-dioxane, tetrahydrofuran (THF), ether, toluene;

    Described solvent B is the one in methyl alcohol, ethanol, Virahol, trifluoroethanol, ethyl acetate, methylene dichloride, Isosorbide-5-Nitrae-dioxane, tetrahydrofuran (THF), ether, toluene;

    Described olefinic amine compound is the compound shown in general formula A1, A2 or A3;

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