Preparation of 18f-fluciclovine

Preparation of 18f-fluciclovine

  • CN 104,507,905 A
  • Filed: 08/07/2013
  • Published: 04/08/2015
  • Est. Priority Date: 08/09/2012
  • Status: Active Application
First Claim
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1. prepare 1-amino-3-[ 18f]-fluorine cyclobutane formate ([ 18f]-FACBC) method, wherein said method comprises:

  • A () provides the formula II compound being adsorbed onto solid phase;

    (II) Wherein;

    PG 1for carboxy protective group;

    And PG 2for amine protecting group group;

    B () makes formula II compound and the PG of described absorption 1protective material is gone to react;

    (c) after described reactions steps (b) by described PG 1protective material is gone to deliver to refuse;

    D () makes elute soln pass described solid phase to obtain the eluting compounds of formula III;

    (III);

    E () makes eluting compounds and the PG of the described formula III obtained in step (d) 2go protective material react being comprised [ 18f] reaction mixture of-FACBC.

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