CYAA-based chimeric proteins comprising a heterologous polypeptide and their uses in the induction of immune responses

CYAA-based chimeric proteins comprising a heterologous polypeptide and their uses in the induction of immune responses

  • CN 104,662,152 A
  • Filed: 07/23/2013
  • Published: 05/27/2015
  • Est. Priority Date: 07/23/2012
  • Status: Active Application
First Claim
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1. encode the polynucleotide of CyaA derived protein, wherein, described CyaA derived protein comprises or is made up of following:

  • 1) fragment of Bordetella pertussis (Bordetella pertussis) the CyaA albumen as shown in SEQ ID NO;

    2, the sequence of described fragment originates in first residue of SEQ ID NO;

    2, and ends at a residue of the 183rd to the 227th that is arranged in SEQ ID NO;

    2;

    Or with described fragment, there is the variant of at least 95% similarity;

    And merge extremely2) fragment of Bordetella pertussis (Bordetella pertussis) the CyaA albumen as shown in SEQ ID NO;

    2, the sequence of described fragment originates in a residue of the 321st to the 387th that is arranged in SEQ ID NO;

    2, and ends at last residue of SEQ ID NO;

    2;

    Or with described fragment, there is the variant of at least 95% similarity.

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