The preparation method of Thienopyrimidine derivative

The preparation method of Thienopyrimidine derivative

  • CN 104,703,992 B
  • Filed: 09/27/2013
  • Issued: 03/05/2019
  • Est. Priority Date: 09/28/2012
  • Status: Active Grant
First Claim
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1. preparing 1- { 4- [1- (2,6- difluorobenzyl) -5- dimethylaminomethyl -3- (6- methoxyl group pyridazine -3- base) -2,4-Dioxo -1,2,3,4- thiophanes simultaneously [2,3-d] pyrimidine -6- base] phenyl -3- methoxyl group urea or its salt method, the sideMethod includes:

  • by 6- (4- aminophenyl) -1- (2,6- difluorobenzyl) -5- dimethylaminomethyl -3- (6- methoxyl group pyridazine -3-Base) thieno [2,3-d] pyrimidine -2,4 (1H, 3H)-diketone or its salt, 1,1'"'"'- carbonyl dimidazoles or its salt and Methoxyamine orIts reactant salt, wherein relative to 6- (4- aminophenyl) -1- (2,6- difluorobenzyl) -5- dimethylaminomethyl -3- (6- firstOxygroup pyridazine -3- base) thieno [2,3-d] pyrimidine -2,4 (1H, 3H)-diketone or its salt, 1,1'"'"'- carbonyl dimidazoles or its saltAmount is 1.6 to 2.5 equivalents, and relative to 1,1'"'"'- carbonyl dimidazoles or its salt, the amount of Methoxyamine or its salt is worked as 1.0 to 1.5Amount.

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