Alkylated cyclodextrin compositions and processes for preparing and using the same

Alkylated cyclodextrin compositions and processes for preparing and using the same

  • CN 104,704,007 A
  • Filed: 02/27/2013
  • Published: 06/10/2015
  • Est. Priority Date: 02/28/2012
  • Status: Active Application
First Claim
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1. preparation comprises the method for the alkylated cyclodextrin composition of alkylated cyclodextrin, and described method comprises:

  • A () makes cyclodextrin mix to form the reaction environment comprising alkylated cyclodextrin, one or more less desirable components and one or more drug degradation impurity with alkylating agent;

    B () is carried out one or more and is separated to remove one or more less desirable components described from described reaction environment, thus formed and comprise the partially purified solution of described alkylated cyclodextrin and one or more drug degradation impurity described, it is ultrafiltration, diafiltration, centrifugal, extraction, solvent deposition or dialysis that wherein said one or more are separated;

    AndC () produces described alkylated cyclodextrin by residual conduction rate for partially purified solution described in the not phosphatic activated carbon treatment of 10 μ

    S or lower.

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