(Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluormethylphenyl)-amide tablet formulations with improved stability

(Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluormethylphenyl)-amide tablet formulations with improved stability

  • CN 104,739,821 A
  • Filed: 09/14/2010
  • Published: 07/01/2015
  • Est. Priority Date: 09/18/2009
  • Status: Active Grant
First Claim
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1. a solid composite medicament, it comprises:

  • A) teriflunomide of 1% to 30% weight ratio or its pharmaceutically acceptable base addition salts,B) disintegrating agent of 5% to 20% weight ratio,C) binding agent of 0% to 40% weight ratio,D) lubricant of 0.1% to 2% weight ratio, andE) remaining percentage ratio comprises diluent,Condition is that described solid composite medicament does not comprise silica sol and pyrimidines or its salt.

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