Small-caliber biotic artificial blood vessel with anti-thrombus formation and anti-intimal hyperplasia functions

Small-caliber biotic artificial blood vessel with anti-thrombus formation and anti-intimal hyperplasia functions

  • CN 104,771,783 A
  • Filed: 04/29/2015
  • Published: 07/15/2015
  • Est. Priority Date: 04/29/2015
  • Status: Active Application
First Claim
Patent Images

1. a small-bore biological artificial blood vessel for antithrombus formation and neointimal hyperplasia, is characterized in that, prepared by following methods:

  • (1) prepare vascular stroma material;

    1. using natural Acellular trachea matrix material as timbering material, the method utilizing this timbering material to adopt tradition to prepare biological artificial blood vessel support prepares biological artificial blood vessel support;

    Or 2. adopt collagen protein, natural silk or polylactic acid to form the electrostatic spinning of one pack system, or utilize collagen protein/natural silk, natural silk/polylactic acid or collagen protein/polylactic acid to form the electrostatic spinning of bi-component, adopt Electrospinning to prepare biological artificial blood vessel support;

    Or 3. adopt 3D printing technique to print biological artificial blood vessel support;

    (2) vascular stroma material is modified;

    hatch described biological artificial blood vessel support with the N-sulfonic acid-photo-crosslinking-sulfated chitosan of 70%-90%, 0.5%-5%d elastin laminin, 10%-20%d collagen, 0.05%-0.1%d heparin and 0.005%-0.05%d RGD peptide;

    (3) coupling neurotrophic factor;

    by 3-(2-pyridine dithio) propanoic acid N-succinimide ester or chitosan, Poly(D,L-lactide-co-glycolide or cyclodextrin, the biological artificial blood vessel support processed through step (2) with neurotrophic factor coupling, thus obtain biological artificial blood vessel.

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