Use of a natural polysaccharide gel for production of an injectable formulation for treating joint degeneration

Use of a natural polysaccharide gel for production of an injectable formulation for treating joint degeneration

  • CN 104,825,482 A
  • Filed: 07/02/2008
  • Published: 08/12/2015
  • Est. Priority Date: 07/02/2007
  • Status: Active Application
First Claim
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1. be used in aqueous compositions that is in intraarticular gap, aseptic, injectable gel form, it comprises 1-100mg/ml molecular weight is 0.1-10 ×

  • 10 6one or more other polysaccharide of a kind of and optional natural origin in the hyaluronic acid of Da or its salt and comprise one or more polyhydric alcohol of 0.0001-100mg/ml, said preparation is by preparing the one comprised in hyaluronic acid or its salt, one or more other polysaccharide of optional natural origin and comprise the Aquo-composition of one or more polyhydric alcohol, then moist heat sterilization is carried out to said composition and obtained, the elastic modulus G '"'"' that the gel wherein obtained has and viscous modulus G " crossover frequency be 0 to 3Hz, preferably 0.41 ±

    0.41Hz, thus G '"'"' is greater than G at high frequencies ", described polyhydric alcohol is selected from glycerol, propylene glycol, sorbitol and mannitol.

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