Preparation method and application of vernonia anthelmintica phenolic acid part

Preparation method and application of vernonia anthelmintica phenolic acid part

  • CN 104,825,519 A
  • Filed: 05/29/2015
  • Published: 08/12/2015
  • Est. Priority Date: 05/29/2015
  • Status: Active Application
First Claim
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1. a preparation method for Caulis Vernoniae andersonii phenolic acid part, is characterized in that following these steps to carry out:

  • A. after the Caulis Vernoniae andersonii fruit of drying being pulverized, be 0-95% methanol, ethanol or aqueous solution by concentration, room temperature-95 DEG C is extracted 1-5 time, extraction time 0.5-3 hour, is cooled to room temperature, filters, merge extractive liquid, be evaporated to without alcohol taste, obtain ethanol extract, the solid-to-liquid ratio of Caulis Vernoniae andersonii fruit and methanol or ethanol water is 1;

    3-30;

    B. the extract concentration obtained by step a is after the dispersion of 0-15% methanol, ethanol or aqueous dissolution;

    filter, then use resin isolation, first wash decontamination with water;

    be 10-95% methanol or ethanol elution by concentration again;

    collect methanol or ethanol elution, concentrating under reduced pressure eliminates solvent, dry;

    namely obtain containing 3;

    the Caulis Vernoniae andersonii phenolic acid part of 5-dicaffeoyl-quinic acid, 4,5-dicaffeoyl-quinic acid and 3,4-dicaffeoyl-quinic acid.

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